Product Details

Description

The Tangential flow ultrafiltration cassettes is a method of separating very small particles and soluble molecules from solutions. This separation is mainly based on the size of particles or molecules , but the permeability of the membrane material will also be affected by the chemical, molecular and charge characteristics of the sample. The Tangential flow ultrafiltration cassette is usually used to separate molecules with a size difference of more than 3-5 times, and is not suitable for molecules of similar size.

The Tangential Flow Ultrafiltration Cassettes Advantage

Superior new materials of construction and improved cassette design increase process safety, reliability, reproducibility, and productivity:

● The feed and permeate screen material for tangential flow ultrafiltration cassettes is made from polypropylene, which is highly resistant to sodium hydroxide.

● Larger feed and permeate ports provide lower pressure drops.

● Tangential flow ultrafiltration cassettes have been designed to provide maximum mass transfer through the membrane, resulting in faster processing times or reduced area installations compared to existing similar cassette formats.

Order Information

Application

Vaccine

Monoclonal antibodies(McAb)

Recombinant proteins

Plasmid

Cell therapy , Gene therapy

Chemical drug

Traditional Chinese medicine injection

Microfiltration (MF) is useful in the early stages of downstream processing for the "recovery" or isolation of bio-product away from bioreactor waste-material and micro-particulates. MF helps to clarify the feed in the upstream harvest (2). Microfiltration can be used to separate microorganisms and suspended particles ranging from .1 to 10 μm in size.

Ultrafiltration (UF) can be introduced to the intermediate phase of the downstream process, preceding or following purification chromatography. Here, UF is an effective method for protein concentration and buffer exchange prior to the polishing chromatography phase. Ultrafiltration separates macro-molecules ranging from 0.001 to 0.1 μm in size.

Nanofiltration (NF) is one available method for end-process sterilization. NF is employed to sterilize the UF retentate from microbes and viruses, and remove insoluble proteins in preparation for formulation and filling. Nanofiltration separates molecules that range from 1-10 nanometers (nm) in size.

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